Posters - BIOCOMPATIBILITY OF A HIGH DK FLUOROSILICONE HYDROGEL DURING EXTENDED WEAR

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Posters

August 2002

BIOCOMPATIBILITY OF A HIGH DK FLUOROSILICONE HYDROGEL DURING EXTENDED WEAR

Carol Morris, PhD, CIBA Vision Corporation, Duluth, Georgia, USA; Valerie Franklin, PhD, Brian Tighe, PhD, Aston Biomaterials Research Unit, Aston University, Birmingham, England; Martha Graham, MSc, Ida Tan, BSc, CIBA Vision Corporation, Duluth, Georgia, USA

Purpose:

To determine the protein and lipid deposition and bacterial colonization of a high Dk fluorosilicone hydrogel during 30NEW.

Method:

The protein and lipid uptake in 35 asymptomatic patients during a 12- month EW trial in Focus Night & Day (24% H20, Dk/t 175 barrers/cm) was established using fluorescence spectrofluorimetry. The lenses were worn for 30 nights, either as weekly removal and replacement, or continuously. In a separate group of 69 patients in the same wear regimens, lenses were aseptically collected and placed in 2mL sterile PBS. After sonication, each lens was cultured and a portion of the sonicate was grown up on a variety of media, and incubation conditions, designed to maximize the identification of organisms present on the lens.

Results:

Focus Night & Day over 30NEW had very low protein deposition, as low as many conventional materials worn on a DW basis. The protein remained at the surface, as confirmed by plasma emission and monitoring (PEEMS). Lipid deposition was on the lower side of levels observed for DW conventional lenses, using the same technique. No abnormal accumulation of lipid classes was found by extraction and high performance liquid chromatography (HPLC). Bacteria (mostly normal eye flora) were present on the lens at the same frequency and numbers at all points during the 30NEW cycle and were below the levels found on some conventional DW lenses. Protein and lipid uptake and bacterial colonization were equivalent for 30 nights, worn either continuously, or removed and replaced weekly.

Conclusions:

The protein and lipid deposition on Focus Night and Day during 30NEW is maintained at very low levels. There is also no bacterial build up during extended wear over 30 nights.

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BIOCOMPATIBILITY OF A HIGH DK FLUOROSILICONE HYDROGEL DURING EXTENDED WEAR - 132KB

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